Vitamin D, cognition, and dementia
Identifieur interne : 001090 ( Main/Exploration ); précédent : 001089; suivant : 001091Vitamin D, cognition, and dementia
Auteurs : Cynthia Balion ; Lauren E. Griffith ; Lisa Strifler ; Matthew Henderson ; Christopher Patterson ; George Heckman ; David J. Llewellyn ; Parminder RainaSource :
- Neurology [ 0028-3878 ] ; 2012.
Abstract
To examine the association between cognitive function and dementia with vitamin D concentration in adults.
Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of global or domain-specific cognitive performance and dementia was diagnosed according to recognized criteria. A vitamin D measurement was required. Two authors independently extracted data and assessed study quality using predefined criteria. The Q statistic and I2 methods were used to test for heterogeneity. We conducted meta-analyses using random effects models for the weighted mean difference (WMD) and Hedge's
Thirty-seven studies were included; 8 contained data allowing mean Mini-Mental State Examination (MMSE) scores to be compared between participants with vitamin D <50 nmol/L to those with values ≥50 nmol/L. There was significant heterogeneity among the studies that compared the WMD for MMSE but an overall positive effect for the higher vitamin D group (1.2, 95% confidence interval [CI] 0.5 to 1.9;
These results suggest that lower vitamin D concentrations are associated with poorer cognitive function and a higher risk of AD. Further studies are required to determine the significance and potential public health benefit of this association.
Url:
DOI: 10.1212/WNL.0b013e31826c197f
PubMed: 23008220
PubMed Central: 3448747
Affiliations:
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Le document en format XML
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<author><name sortKey="Griffith, Lauren E" sort="Griffith, Lauren E" uniqKey="Griffith L" first="Lauren E." last="Griffith">Lauren E. Griffith</name>
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<author><name sortKey="Strifler, Lisa" sort="Strifler, Lisa" uniqKey="Strifler L" first="Lisa" last="Strifler">Lisa Strifler</name>
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<author><name sortKey="Henderson, Matthew" sort="Henderson, Matthew" uniqKey="Henderson M" first="Matthew" last="Henderson">Matthew Henderson</name>
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<author><name sortKey="Patterson, Christopher" sort="Patterson, Christopher" uniqKey="Patterson C" first="Christopher" last="Patterson">Christopher Patterson</name>
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<author><name sortKey="Heckman, George" sort="Heckman, George" uniqKey="Heckman G" first="George" last="Heckman">George Heckman</name>
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<author><name sortKey="Llewellyn, David J" sort="Llewellyn, David J" uniqKey="Llewellyn D" first="David J." last="Llewellyn">David J. Llewellyn</name>
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<author><name sortKey="Raina, Parminder" sort="Raina, Parminder" uniqKey="Raina P" first="Parminder" last="Raina">Parminder Raina</name>
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<series><title level="j">Neurology</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>To examine the association between cognitive function and dementia with vitamin D concentration in adults.</p>
</sec>
<sec><title>Methods:</title>
<p>Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of global or domain-specific cognitive performance and dementia was diagnosed according to recognized criteria. A vitamin D measurement was required. Two authors independently extracted data and assessed study quality using predefined criteria. The Q statistic and I<sup>2</sup>
methods were used to test for heterogeneity. We conducted meta-analyses using random effects models for the weighted mean difference (WMD) and Hedge's <italic>g</italic>
.</p>
</sec>
<sec><title>Results:</title>
<p>Thirty-seven studies were included; 8 contained data allowing mean Mini-Mental State Examination (MMSE) scores to be compared between participants with vitamin D <50 nmol/L to those with values ≥50 nmol/L. There was significant heterogeneity among the studies that compared the WMD for MMSE but an overall positive effect for the higher vitamin D group (1.2, 95% confidence interval [CI] 0.5 to 1.9; <italic>I</italic>
<sup>2</sup>
= 0.65; <italic>p</italic>
= 0.002). The small positive effect persisted despite several sensitivity analyses. Six studies presented data comparing Alzheimer disease (AD) to controls but 2 utilized a method withdrawn from commercial use. For the remaining 4 studies the AD group had a lower vitamin D concentration compared to the control group (WMD = −6.2 nmol/L, 95% CI −10.6 to −1.8) with no heterogeneity (<italic>I</italic>
<sup>2</sup>
< 0.01; <italic>p</italic>
= 0.53).</p>
</sec>
<sec><title>Conclusion:</title>
<p>These results suggest that lower vitamin D concentrations are associated with poorer cognitive function and a higher risk of AD. Further studies are required to determine the significance and potential public health benefit of this association.</p>
</sec>
</div>
</front>
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<name sortKey="Griffith, Lauren E" sort="Griffith, Lauren E" uniqKey="Griffith L" first="Lauren E." last="Griffith">Lauren E. Griffith</name>
<name sortKey="Heckman, George" sort="Heckman, George" uniqKey="Heckman G" first="George" last="Heckman">George Heckman</name>
<name sortKey="Henderson, Matthew" sort="Henderson, Matthew" uniqKey="Henderson M" first="Matthew" last="Henderson">Matthew Henderson</name>
<name sortKey="Llewellyn, David J" sort="Llewellyn, David J" uniqKey="Llewellyn D" first="David J." last="Llewellyn">David J. Llewellyn</name>
<name sortKey="Patterson, Christopher" sort="Patterson, Christopher" uniqKey="Patterson C" first="Christopher" last="Patterson">Christopher Patterson</name>
<name sortKey="Raina, Parminder" sort="Raina, Parminder" uniqKey="Raina P" first="Parminder" last="Raina">Parminder Raina</name>
<name sortKey="Strifler, Lisa" sort="Strifler, Lisa" uniqKey="Strifler L" first="Lisa" last="Strifler">Lisa Strifler</name>
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